abstract：:The development and validation of a reversed-phase liquid chromatographic method for the determination of the related substances of 2-[N-[(S)-1-Ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-(1S, 3S, 5S)-2-azabicyclo[3.3.0]octane-3-carboxylic acid (ramipril) in Altace capsules is described. The method utilizes an ion-pairin...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Hogan BL,Williams M,Idiculla A,Veysoglu T,Parente E

更新日期：2000-09-01 00:00:00

abstract：:Novel approaches to the development of analytical procedures for monitoring incoming starting material in support of chemical/pharmaceutical processes are described. High technology solutions were utilized for timely process development and preparation of high quality clinical supplies. A single robust HPLC method was...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Sheldon EM,Downar JB

更新日期：2000-08-15 00:00:00

abstract：:A high-performance chromatographic method is described for simultaneous determination of ambroxol in the presence of different preservatives in syrups. The method separates ambroxol from methyl- ethyl-, propyl- and butyl paraben and from other multi-component mixtures. The retention behaviour of ambroxol and parabens ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Koundourellis JE,Malliou ET,Broussali TA

更新日期：2000-08-15 00:00:00

abstract：:Eriochrome cyanine R (ECR) has been tested as reagent for the determination of imipramine. It reacts in neutral medium with imipramine forming reddish compound, which can be quantitatively extracted into n-butanol. This property has been successfully used for the extractive-spectrophotometric determination of imiprami...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Starczewska B

更新日期：2000-08-15 00:00:00

abstract：:In the present study, a simple, sensitive and rapid reversed-phase high performance liquid chromatographic (HPLC) method with ultraviolet detection for the analysis of oxytetracycline (OTC) is developed and applied to the determination of the antibiotic in commercial pharmaceutical preparations (powder, capsules, vagi...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Papadoyannis IN,Samanidou VF,Kovatsi LA

更新日期：2000-08-15 00:00:00

abstract：:Determination of anthocyanins in fresh and concentrated juices can be a parameter for the assessment of authenticity and quality of blood orange juices. This work reports an HPLC/UV-Vis method developed for quantitative determination of anthocyanins in blood orange juices, by using a calibration curve obtained for sta...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Mondello L,Cotroneo A,Errante G,Dugo G,Dugo P

更新日期：2000-08-01 00:00:00

abstract：:Capillary electrophoresis (CE) was used for the simultaneous chiral determination of venlafaxine (Vx), a new antidepressant drug and its main active metabolite. O-desmethyl venlafaxine (ODV). Among the charged cyclodextrins (CD) tested, phosphated gamma-CD was the most appropriate. Resolution of Vx and ODV was obtaine...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Rudaz S,Stella C,Balant-Gorgia AE,Fanali S,Veuthey JL

更新日期：2000-08-01 00:00:00

abstract：:The photostability of melatonin, a hormone used as supplementary drug in the alleviation of jet-lag and other sleep disorders, was studied. The drug photodegradation at different pH values was monitored by HPLC methods. The main photoproduct was isolated and characterised on the basis of the NMR, FTIR, and mass spectr...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Andrisano V,Bertucci C,Battaglia A,Cavrini V

更新日期：2000-08-01 00:00:00

abstract：:A reversed-phase HPLC method is reported for simultaneous quantitation of methylprednisolone (MP), MP succinate (MPS), and endogenous corticosterone (CST) in plasma of rats. Additionally, the 11-keto metabolite of MP (methylprednisone, MPN) is resolved from the other analytes. After addition of internal standard (tria...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Mehvar R,Dann RO,Hoganson DA

更新日期：2000-07-01 00:00:00

abstract：:A comparison of two spectrophotometric methods and a HPLC method were described in this work for the analysis of pyridoxine hydrochloride and thiamine hydrochloride in a vitamin combination. In the first method, A(1)1 (1%, 1 cm) values of these two compounds were calculated using absorbances measured at 246.8 and 290....

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Din E,Kökdil G,Onur F

更新日期：2000-07-01 00:00:00

abstract：:A selective method for the determination of sulphobutylether-beta-cyclodextrin (SBECD) in human plasma has been developed and validated over the range 4-200 microg ml(-1). SBECD is extracted from plasma using end-capped cyclohexyl solid phase extraction cartridges. This is followed by high performance size exclusion c...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Gage R,Venn RF,Bayliss MA,Edgington AM,Roffey SJ,Sorrell B

更新日期：2000-06-01 00:00:00

abstract：:Uridinediphosphoglucuronosyl transferases (UGTs) are a group of membrane bound proteins which catalyze the transfer of glucuronic acid from UDP-glucuronic acid to a wide variety of xenobiotics and drug molecules enabling them to be eliminated. The major UGT isoforms found in the rat are 1A1, 1A6, 2B1 and 2B12. Convent...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Narayanan R,LeDuc B,Williams DA

更新日期：2000-04-01 00:00:00

abstract：:Capillary electrophoresis (CE) was applied to the determination of angiotensin-converting enzyme (ACE) inhibitors in pharmaceuticals (tablets). Since a free solution CE system failed to reach a complete separation of closely related compounds (lisinopril, ramipril, benazepril, quinapril), alkylsulfonic additives (sodi...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Gotti R,Andrisano V,Cavrini V,Bertucci C,Furlanetto S

更新日期：2000-04-01 00:00:00

abstract：:Simple spectrophotometric and spectrofluorimetric methods are suggested for the determination of antifungal drugs; clotrimazole, econazole nitrate, ketoconazole, miconazole and tolnaftate. Spectrophotometric one depends on the interaction between imidazole antifungal drugs as n-electron donor with the pi acceptor 2,3-...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Khashaba PY,El-Shabouri SR,Emara KM,Mohamed AM

更新日期：2000-03-01 00:00:00

abstract：:A rapid, specific and very sensitive liquid chromatographic assay using standard ultraviolet detection has been developed to measure cefazolin (CFZ) or ceftriaxone (CFX) in small samples (200 microl) of plasma using either drug as the internal standard for measurement of the other. A rapid extraction was performed usi...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Al-Rawithi S,Hussein R,Raines DA,AlShowaier I,Kurdi W

更新日期：2000-03-01 00:00:00

abstract：:Capillary electrophoresis with conductivity detection is a selective and quantitative method for the analysis of counter cations, such as potassium, in pharmaceutical drug substances. It is also a sensitive and specific technique for screening and measuring inorganic impurities in drug substance samples. Both counter ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Williams RC,Boucher RJ

更新日期：2000-02-01 00:00:00

abstract：:The simultaneous interaction of 15 steroidal drugs with tau-cyclodextrin (tauCD) and hydroxypropyl-beta-CD (HPbetaCD) was determined by charge transfer chromatography and the relative strength of interaction was calculated for each drug-tauCD-HPbetaCD ternary complex. The mixture of CDs interacted with each steroidal ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Cserháti T,Forgács E

更新日期：2000-02-01 00:00:00

abstract：:Piracetam (2-oxo-1-pyrrolidine acetamide (PAm)) may contain some structurally related impurities deriving from synthesis or degradation, mainly 2-oxo-1-pyrrolidine acetic acid (PAc). A rapid and sensitive Fourier transform infrared (FTIR) spectrophotometric method was developed for determination of possible impurities...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Karamancheva I,Staneva T

更新日期：2000-01-01 00:00:00

abstract：:A micro-bore liquid chromatographic method was developed for the simultaneous determination of benazepril hydrochloride and hydrochlorothiazide in pharmaceutical dosage forms. The use of a BDS C-18 micro-bore analytical column, results in substantial reduction in solvent consumption and increased sensitivity. The mobi...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Panderi IE,Parissi-Poulou M

更新日期：1999-12-01 00:00:00

abstract：:The stability of quinine was determined in various diluents and in polyvinyl chloride (PVC) containers. The release of diethyhexyl phthalate (DEHP) from PVC bags into intravenous infusions of quinine was also measured. We used an injection of two doses of quinine; quiniforme at 500 mg and quinimax at 400 mg in either ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Faouzi MA,Khalfi F,Dine T,Luyckx M,Brunet C,Gressier B,Goudaliez F,Cazin M,Kablan J,Belabed A,Cazin JC

更新日期：1999-12-01 00:00:00

abstract：:A method has been developed for the quantitative determination of low concentrations of sufentanil citrate (1.0 microg/ml), in the presence of bupivacaine hydrochloride (0.125%), in the quality control of pharmaceutical preparations. The main problem in analysis of this combination is the low concentration of sufentan...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Movig KL,Langen MC,Egberts AC

更新日期：1999-12-01 00:00:00

abstract：:Therapeutic monitoring of the potent, highly lipophilic glucocorticoid, fluticasone propionate (FP), was initially performed by a radioimmunoassay method. However an improved method with a lower limit of quantitation (LLOQ) of at least 25 pg per ml (pg/ml(-1)) was needed to measure the low levels of FP present in huma...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Laugher L,Noctor TG,Barrow A,Oxford JM,Phillips T

更新日期：1999-12-01 00:00:00

abstract：:A method is presented for the direct determination of mephenoxalone and acetaminophen in combined pharmaceutical dosage forms without prior separation. The first method, derivative-differential spectrophotometry, comprised of measurement of the difference absorptivities derivatized in the first order (deltaD1) of a ta...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Erk N

更新日期：1999-11-01 00:00:00

abstract：:The validation of an analytical method for the quantitative determination of erythromycin thiocyanate formulated in an antibiotic preparation for veterinary use was carried out. This method is based on the microbiological method described in the European Pharmacopoeia to analyze erythromycin thiocyanate as a raw mater...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Bernabéu JA,Camacho MA,Gil-Alegre ME,Ruz V,Torres-Suárez AI

更新日期：1999-11-01 00:00:00

abstract：:A second-order derivative spectrophotometric method for the simultaneous determination of benazepril hydrochloride and hydrochlorothiazide in pharmaceutical dosage forms is described. The determination of benazepril hydrochloride in the presence of hydrochlorothiazide was achieved by measuring the second-order derivat...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Panderi IE

更新日期：1999-11-01 00:00:00

abstract：:We describe here the development of a new, non-isotopic immunological assay termed CMIA (carbonyl metallo immunoassay) that uses metal carbonyl complexes as tracers and Fourier transform infrared spectroscopy (FT-IR) as the detection method. This assay is based on the particular spectral features of these complexes, w...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Vessières A,Salmain M,Brossier P,Jaouen G

更新日期：1999-11-01 00:00:00

abstract：:Three methods are described for the simultaneous determination of mebeverine hydrochloride (MB) and sulpiride (SU) in combined pharmaceutical tablets. The first method depends on first-derivative ultraviolet spectrophotometry, with zero-crossing measurement method. The first derivative amplitudes at 214.2 and 221.6 nm...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： El Walily AF,El Gindy A,Bedair MF

更新日期：1999-11-01 00:00:00

abstract：:Spectrophotometric procedures are presented for the determination of two commonly used antidepressant drugs, fluoxetine (I) and sertraline hydrochloride (II). The methods are based mainly on charge transfer complexation reaction of these drugs with either pi acceptors chloranil and 2, 3 dichloro-5, 6-dicyanoquinone (D...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Bebawy LI,El-Kousy N,Suddik JK,Shokry M

更新日期：1999-10-01 00:00:00

abstract：:The H-point standard additions method (HPSAM) and two versions of the generalized H-point standard additions method (GHPSAM) are evaluated for the UV-analysis of two-component mixtures. Synthetic mixtures of anhydrous caffeine and phenazone as well as of atovaquone and proguanil hydrochloride were used. Furthermore, t...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Hund E,Massart DL,Smeyers-Verbeke J

更新日期：1999-10-01 00:00:00

abstract：:Opiates are commonly abused substances, and forensic urine drug-testing for them requires gas chromatographic-mass spectrometric (GC-MS) confirmation. There are also medical reasons to test urine for opiates, and confirmation procedures other than GC-MS are often used for medical drug-testing. A thin-layer chromatogra...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Nowatzke W,Zeng J,Saunders A,Bohrer A,Koenig J,Turk J

更新日期：1999-09-01 00:00:00

abstract：:The present work describes a quantitative thin layer procedure for estimating primidone, clorazepate dipotassium and chlorzoxazone in bulk powders and in dosage forms, each in the presence of its degradation product. The method consists of dissolving the drug in ethanol (for primidone), or methanol (for clorazepate di...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： El Bayoumi AA,Amer SM,Moustafa NM,Tawakkol MS

更新日期：1999-09-01 00:00:00

abstract：:Human polyvalent intravenous immunoglobulin (IVIG) preparations are used as a complementary aid to the proper antimicrobial treatment of severely septic patients in intensive care units (ICUs) and/or as a prophylactic agent to immunocompromised hosts, particularly prone to bacterial infections. There is skepticism abo...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Lamari F,Anastassiou ED,Tsegenidis T,Dimitracopoulos G,Karamanos NK

更新日期：1999-09-01 00:00:00

abstract：:The stability indicating properties of the USP method for the assay of fentanyl in fentanyl citrate injection were evaluated [1] by analyzing fentanyl drug substance and product after acid, hydrogen peroxide, heat, and light treatment. N-phenyl-N-(4-piperidinyl)propionamide (PPA), which is a known degradation product/...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Lambropoulos J,Spanos GA,Lazaridis NV,Ingallinera TS,Rodriguez VK

更新日期：1999-08-01 00:00:00

abstract：:Doxorubicin is one of the most potent anti-tumor agents generally used in the treatment of bone cancer. A simple and sensitive HPLC method was developed and validated for the assay of doxorubicin. The method used a C18 Luna microbore column (50 x 1 mm) with a fluorescent detector (505 nm Ex. and 550 nm Em.). The mobil...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Zhao P,Dash AK

更新日期：1999-07-01 00:00:00

abstract：:A robust gradient high performance liquid chromatographic (HPLC) procedure is described for the simultaneous determination of melphalan content and related impurities in melphalan drug substance. The sample solution is prepared in methanol and injected. A linear gradient from 5 to 60% acetonitrile in water containing ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Brightman K,Finlay G,Jarvis I,Knowlton T,Manktelow CT

更新日期：1999-07-01 00:00:00

abstract：:Reliable methods for the analysis of silicon are of great importance, because it seems that the silicate anion can reduce aluminum bioavailability in patients undergoing dialysis. Thus, a simple and sensitive spectrophotometric method is described for the determination of silicate traces in dialysis solutions. The met...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Raggi MA,Sabbioni C,Mandrioli R,Zini Q,Varani G

更新日期：1999-06-01 00:00:00

abstract：:The use of multivariate spectrophotometric calibration is reported for the analysis of two decongestant tablets, where paracetamol is the principal component and diphenhydramine or phenylpropanolamine are the minor components. The resolution of these mixtures has been accomplished without prior separation or derivatis...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Goicoechea HC,Olivieri AC

更新日期：1999-06-01 00:00:00

abstract：:We have developed a simple and rapid time-resolved fluoroimmunoassay (TR-FIA) for simultaneous determination of alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG) and estriol (E3) using europium and samarium ion chelate. In the proposed method, we used a combination of a 96-well microtiter plate for the AFP a...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Ito K,Oda M,Tsuji A,Maeda M

更新日期：1999-06-01 00:00:00

abstract：:An HPLC-UV method was developed for assay of linezolid in dog, rat, mouse, and rabbit plasma. Linezolid and the internal standard were extracted on a solid phase cartridge (SPE) and separated on a reversed-phase column (C8, 4.6x150 mm, 5 microm) with 20% acetonitrile in water as mobile phase. The SPE quantitatively re...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Peng GW,Stryd RP,Murata S,Igarashi M,Chiba K,Aoyama H,Aoyama M,Zenki T,Ozawa N

更新日期：1999-06-01 00:00:00

abstract：:A quick and sensitive method has been developed and validated for the determination of tungsten in bulk drug substance and intermediates using either Inductively Coupled Plasma Atomic Emission Spectrometry (ICP-AES) or Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Sample preparation is by direct dissolution w...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Wang T,Ge Z,Wu J,Li B,Liang A

更新日期：1999-05-01 00:00:00